Base de dados : HANSEN Pesquisa : COMPLEMENTO 1/METAB [Descritor de assunto] Referências encontradas : 3 [refinar] Mostrando: 1 .. 3   no formato [Detalhado]

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Id: 18136 Autor: Bjorvatn, B; Barnetson, R. S; Kronvall, G; Zubler, R. H; Lambert, P. H Título: Immune complexes and complement hypercatabolism in patients with leprosy ..- Fonte: s.l; s.n; dec. 1976. 9 p. tab, graf. Resumo: The occurrence of immune complexes in the serum and the level of the C3 breakdown product C3d in the plasma from patients with leprosy were studied by quantitative methods and the results were compared in various forms of the disease. These studies were performed on sixty-two samples from twenty-six patients. The serum 125I-C1q binding activity was found to be increased by more than 2 s.d., as compared to the normal values, in most of the sera from patients with erythema nodosum leprosum (ENL) (80%) and uncomplicated lepromatous leprosy (82%), but also in the sera from patients with tuberculoid leprosy (58%). In vitro studies suggested that immune complexes involving mycobacterial antigens were present in leprosy sera. An increased C3d level (greater than 2s.d.) was also found in most of the plasma from patients with ENL (70%), but rarely in the plasma from patients with uncomplicated lepromatous leprosy (18%) and never in tuberculoid leprosy patients' plasma. The absence of a significant correlation between the 125I-C1q binding activity and the C3d level in leprosy patients may suggest that extravascular immune complexes are involved in the complement activation occurring in ENL. The quantitation of C3d in plasma may be of some practical interest in the early diagnosis of ENL complications of leprosy.(AU). Descritores: COMPLEXO ANTIGENO-ANTICORPO COMPLEMENTO 1/metab COMPLEMENTO 3/metab TESTES DE FIXACAO DE COMPLEMENTO ERITEMA NODOSO/imunol HANSENIASE/imunol Limites: HUMANO ADULTO Meio Eletrônico: - . Localização: BR191.1; 00016/s

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Id: 18034 Autor: Bjorvatn, B; Barnetson, R. S; Kronvall, G; Zubler, R. H; Lambert, P. H Título: Immune complexes and complement hypercatabolism in patients with leprosy ..- Fonte: s.l; s.n; dec. 1976. 9 p. tab, graf. Resumo: The occurrence of immune complexes in the serum and the level of the C3 breakdown product C3d in the plasma from patients with leprosy were studied by quantitative methods and the results were compared in various forms of the disease. These studies were performed on sixty-two samples from twenty-six patients. The serum 125I-C1q binding activity was found to be increased by more than 2 s.d., as compared to the normal values, in most of the sera from patients with erythema nodosum leprosum (ENL) (80%) and uncomplicated lepromatous leprosy (82%), but also in the sera from patients with tuberculoid leprosy (58%). In vitro studies suggested that immune complexes involving mycobacterial antigens were present in leprosy sera. An increased C3d level (greater than 2s.d.) was also found in most of the plasma from patients with ENL (70%), but rarely in the plasma from patients with uncomplicated lepromatous leprosy (18%) and never in tuberculoid leprosy patients' plasma. The absence of a significant correlation between the 125I-C1q binding activity and the C3d level in leprosy patients may suggest that extravascular immune complexes are involved in the complement activation occurring in ENL. The quantitation of C3d in plasma may be of some practical interest in the early diagnosis of ENL complications of leprosy.(AU). Descritores: COMPLEMENTO 3/metab TESTES DE FIXACAO DE COMPLEMENTO ERITEMA NODOSO/imunol HANSENIASE/imunol COMPLEMENTO 1/metab COMPLEXO ANTIGENO-ANTICORPO Limites: HUMANO ADULTO Meio Eletrônico: - . Localização: BR191.1; 01833/s

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Id: 17976 Autor: Tung, K. S; Kim, B; Bjorvatn, B; Kronvall, G; McLaren, L. C; Williams, R. C Título: Discrepancy between Clq deviation and Raji cell tests in detection of circulating immune complexes in patients with leprosy ..- Fonte: s.l; s.n; aug. 1977. 6 p. ilus, tab, graf. Resumo: Samples of serum from 45 patients with different clinical forms of leprosy and from 17 patients with systemic lupus erythematosus were studied in parallel for circulating immune complexes with use of two different in vitro tests adjusted to the same degree of sensitivity. The Clq deviation test relied upon the reaction of the complement component Clq with immune complexes. The Raji cell test detected complement-fixed immune complexes that bound to the complement receptors on cultured, bone marrow-derived lymphocyte-like Raji cells. Thirty (67%) of 45 patients with leprosy showed immune complexes according to the Clq deviation test; however, only two (7%) of the 30 samples of sera with positive Clq test results were positive by the Raji cell test. In contrast, 54% of 13 samples of sera from patients with systemic lupus erythematosus positive by the Clq test were positive according to the Raji cell test. Since Clq is known to react with DNA as well as with bacterial antigens, the Clq reaction may in fact be detecting antigenemia in many instances. Considerable caution is warranted in application of sensitive screening tests for assay of circulating immune complexes in various states of infectious diseases.(AU). Descritores: HANSENIASE/imunol TECNICAS IMUNOLOGICAS DNA/imunol DNA/metab ANTICORPOS COMPLEXO ANTIGENO-ANTICORPO LINHAGEM CELULAR COMPLEMENTO/metab COMPLEMENTO 1/metab LUPUS ERITEMATOSO SISTÊMICO/imunol Limites: ESTUDO COMPARATIVO HUMANO SUPPORT, U.S. GOV'T, P.H.S. Meio Eletrônico: - . Localização: BR191.1; 01271/s

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